Synthesis and Characterization of Novel Hybrid Isoindole Molecules with Thiazole Scaffold

Thiazole-based compounds exhibit a broad spectrum of bioactivities, including anticancer, antidiabetic, antiviral, antituberculosis, antimalarial, analgesic, anti-inflammatory, antimicrobial, and fungicidal properties. Likewise, isoindole-containing compounds have demonstrated remarkable biological potential, particularly as inhibitors of enzymes such as carbonic anhydrase, HIV (Human Immunodeficiency Virus) protease, cysteine protease, and cyclooxygenase (COX-II), in addition to their antibacterial and antibiotic applications. Given the diverse biological activities of thiazole and isoindole scaffolds, their incorporation into synthetic organic compounds has attracted significant attention from medicinal chemists. In recent years, the design of molecular hybrids has focused on integrating at least two pharmacophoric elements, thereby enabling the simultaneous modulation of multiple disease-related targets. Accordingly, molecular hybridization emerges as a modern strategy for developing multifunctional hybrid molecules by combining distinct pharmacophores within a single structural framework. In this study, hybrid molecules (5a-c and 6a-c), which have potential applications in various therapeutic areas, were effectively synthesized from thiazole derivatives (2a-c) obtained through a series of reactions initiated by acetophenone (1a-c) and carboxylic anhydride (3,4) compounds. The structures of the obtained molecules were detected with spectrometric analysis methods (Fourier Transform Infrared Spectroscopy (FT-IR), Nuclear Magnetic Resonance (NMR-Proton NMR (1H NMR), Carbon NMR (13C NMR), and High-Resolution Mass Spectrometry (HRMS)).