What question did this study set out to answer?

To isolate and characterize chemical compounds from Daphne genkwa and evaluate their α-glucosidase inhibitory activity.

January 6, 2026Letters in Organic Chemistry0 citations

Isolation, Identification, and α-Glucosidase Inhibitory Activity of the Chemical Composition of Daphne genkwa

JLJia-Zi LuoAffiliated Hospital of Youjiang Medical University for Nationalities XSXi-Xi SongGuangxi Normal University GWGang WeiGuangxi Normal University

Key Points

To isolate and characterize chemical compounds from Daphne genkwa and evaluate their α-glucosidase inhibitory activity.
Phytochemical investigation of Daphne genkwa
Isolation of one new indole alkaloid and twenty-three known compounds
Categorization of compounds into alkaloids, yuanhuacin derivatives, lignans, flavonoids, and monoterpene
Spectroscopic analysis using UV, HRESIMS, and 1D/2D NMR techniques
Evaluation of α-glucosidase inhibitory activity with IC50 values
One previously undescribed indole alkaloid was isolated and identified.
Compounds included three alkaloids, eight yuanhuacin derivatives, seven lignans, five flavonoids, and one monoterpene.
Moderate α-glucosidase inhibitory effects were observed in compounds 11, 20, and 23 with IC50 values of 13.39, 16.64, and 18.04 μM, respectively.
Certain constituents of D. genkwa show potential as α-glucosidase inhibitors.

Abstract

Abstract: Phytochemical investigation of Daphne genkwa led to the isolation and identification of one previously undescribed indole alkaloid (1) and twenty-three known compounds. The isolated compounds were categorized as follows: three alkaloids (1–3), eight yuanhuacin derivatives (4–11), seven lignans (12–18), five flavonoids (19–23), and one monoterpene (24). The structure of the new indole alkaloid (1) was elucidated through comprehensive spectroscopic analysis, including UV, HRESIMS, and 1D/2D NMR techniques. All isolated compounds were evaluated for their α- glucosidase inhibitory activity. Among them, compounds 11, 20, and 23 exhibited moderate inhibitory effects, with IC50 values of 13.39, 16.64, and 18.04 μM, respectively. These findings suggest that certain constituents of D. genkwa might hold potential as α-glucosidase inhibitors, warranting further investigation into their therapeutic applications.

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