Enantioselective Cyclization of Bromoenynes: Mechanistic Understanding of Gold(I)-Catalyzed Alkoxycyclizations

Key Points

• To explore the enantioselective cyclization process of bromoenynes using gold(I) catalysts.
• Achieved alkoxycyclization using a modified JohnPhos ligand.
• Utilized a chiral catalyst to enhance selectivity and yield.
• Successfully demonstrated enantioselective cyclization in bromo-1,6-enynes.
• Improved yields observed when using the C2-chiral 2,5-diarylpyrrolidine ligand.