Key result
Exercise aggravated the ECG phenotype in Brugada syndrome with SCN5A mutation leading to greater QRS widening compared to those without the mutation and controls.
Why the study?
Does exercise aggravate the ECG phenotype in male patients with Brugada syndrome?
Population
Male patients aged 20-65 years with Brugada syndrome and healthy male control subjects
Comparison
Exercise test vs Healthy male control subjects undergoing…
Design
Cohort, ECG analysis performed by 1 blinded and 1 unblinded reviewer…
Authors
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Exercise-induced QRS widening may warrant caution in SCN5A+ BrS; extends experimental rate-dependent conduction slowing to clinical phenotypes.
Does exercise aggravate the ECG phenotype in male patients with Brugada syndrome?
Exercise aggravates the ECG phenotype in Brugada syndrome, with the presence of an SCN5A mutation associated with further conduction slowing at fast heart rates.
Amin et al. (2009) studied this question. Exercise aggravated the ECG phenotype in Brugada syndrome with SCN5A mutation leading to greater QRS widening compared to those without the mutation and controls.
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