Key result
iPSC cardiomyocytes mirror prenatal transcriptomes but show diverse splicing across early and late development.
Why the study?
Although iPSC-derived cardiomyocytes are widely used in cardiovascular research, the extent to which they recapitulate native cardiac alternative splicing patterns remains poorly understood.
Population
Human induced pluripotent stem cell-derived cardiomyocytes and native human cardiac tissue
Comparison
iPSC-derived cardiomyocytes vs native human cardiac developmental stages
Design
In vitro and in vivo translational study
Authors
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iPSC-CMs warrant caution as mature models for splicing studies; leaves open need for validated maturation protocols.
This study provides a comprehensive map of alternative splicing during human cardiac development, revealing that iPSC-derived cardiomyocytes have heterogeneous splicing profiles that may limit their utility as fully mature models.
Gomes-Silva et al. (2026) studied this question. iPSC-derived cardiomyocytes recapitulate prenatal transcriptomes but show heterogeneous splicing profiles, reflecting both early and later-stage cardiac development.
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