February 12, 2024EBioMedicineOpen Access

Therapeutic potential of alternative splicing in cardiovascular diseases

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Authors

JCJun CaoSun Yat-sen University ZWZiyu WeiJiangnan University YNYu NieSouth China Agricultural University

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Implication

Review reveals alternative splicing mechanisms and target genes in cardiovascular disease, highlighting emerging therapeutic strategies for cardiac disorders.

Key Points

Pathological alternative splicing disrupts sarcomeric genes and ion channel genes in cardiovascular disease, leading to cellular dysfunction through nonsense-mediated decay.
Analysis across genetic animal models identifies critical splicing factors regulating cardiac development, with aberrant rna splicing driving functional loss in heart tissue.
Targeting aberrant alternative splicing highlights promising therapeutic strategies for cardiovascular diseases, though further translation beyond animal models remains necessary.

Cite This Study

Cao et al. (2024) studied this question.

synapsesocial.com/papers/68e796dbb6db643587707c2e https://doi.org/10.1016/j.ebiom.2024.104995

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Implication

Review reveals alternative splicing mechanisms and target genes in cardiovascular disease, highlighting emerging therapeutic strategies for cardiac disorders.

Therapeutic potential of alternative splicing in cardiovascular diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

Therapeutic potential of alternative splicing in cardiovascular diseases

Discussion

Member takes

Implication

Key Points

Cite This Study

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