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This review investigates the role of alternative splicing in cardiovascular health and disease, focusing on its mechanisms and clinical implications.

June 7, 2026

RNA splicing and cardiovascular disease: a guide for cardiologists.

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Review examines RNA splicing's impact on cardiovascular disease, highlighting diagnostics and therapeutics implications.

This review investigates the role of alternative splicing in cardiovascular health and disease, focusing on its mechanisms and clinical implications.
Examined cardiac-enriched RNA-binding proteins and their influence on heart-specific splicing.
Summarized diagnostic opportunities using bulk, long-read, and single-cell transcriptomics.
Outlined therapeutic strategies for modulating alternative splicing in cardiovascular disease.
Alternative splicing influences pathogenesis in various cardiomyopathies.
Distinct splicing signatures are identified between physiological and pathological hypertrophy.
Therapeutic strategies, including genome editing and antisense oligonucleotides, are discussed for future application.

Hunt et al. (2026) studied this question.

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