Higher remnant cholesterol levels were significantly associated with increased risk of trouble sleeping, with an odds ratio of 1.30 (95% CI: 1.13–1.49).
Does higher remnant cholesterol correlate with self-reported trouble sleeping in U.S. adults?
Higher remnant cholesterol levels are independently associated with an increased risk of self-reported trouble sleeping in U.S. adults, a relationship partially mediated by depression.
Absolute Event Rate: 0% vs 0%
ABSTRACT Purpose Remnant cholesterol (RC) is an independent risk factor for cardiovascular diseases. The objective of this study is to assess the correlation between RC levels and trouble sleeping among U.S. adults. Methods This study analyzed data from 14,617 adults enrolled in the National Health and Nutrition Examination Survey (NHANES), calculating RC by subtracting both high‐density and low‐density lipoprotein cholesterol (HDL‐c and LDL‐c) from total cholesterol (TC). Trouble sleeping was identified through self‐report history. The relationship between RC and trouble sleeping was explored through logistic regression, restricted cubic spline (RCS), and mediation analysis. Results The prevalence of trouble sleeping escalates with increasing RC levels. Adjusting for potential confounders, higher RC levels were significantly associated with an increased risk of trouble sleeping OR (95% CI): 1.30 (1.13–1.49), p < 0.001. A linear relationship was identified through RCS analysis. Moreover, depression was found to partially mediate the relationship between RC and trouble sleeping. Conclusions Trouble sleeping is associated with increased RC levels. The causal relationship requires additional investigation.
Yang et al. (Thu,) reported a other. Higher remnant cholesterol levels were significantly associated with increased risk of trouble sleeping, with an odds ratio of 1.30 (95% CI: 1.13–1.49).