What question did this study set out to answer?

This research aims to document the clinical characteristics and outcomes of patients with SMART syndrome.

January 10, 2026

Case series of SMART syndrome in a tertiary hospital in Gran Canaria

AFA. Relloso de la FuenteHospital Universitario de Gran Canaria Doctor Negrín JGJ.F. García GranadoHospital Universitario de Gran Canaria Doctor Negrín OMO.G. Quesada MoralesHospital Universitario de Gran Canaria Doctor Negrín

Key Points

This research aims to document the clinical characteristics and outcomes of patients with SMART syndrome.
Retrospective analysis of patient records

Structured PICO

Population

3 patients who developed focal neurological symptoms after receiving holocranial radiotherapy for brain tumours

Outcome

Diagnosis of SMART syndrome

Highlights the occurrence of SMART syndrome as a complication of holocranial radiotherapy to raise awareness among professionals.

Abstract

INTRODUCTION SMART (stroke-like migraine attacks after radiation therapy) syndrome is a possible complication of radiotherapy used in the treatment of brain tumours. The current prevalence is not well known, partly because it is underdiagnosed. MATERIAL AND METHODS A descriptive, prospective study was designed over a period of 18 months. Demographic, clinical, analytical and neuroimaging variables were collected. RESULTS Three patients were included who, after receiving holocranial radiotherapy, developed focal neurological symptoms after a variable latency period. After ruling out other possible aetiologies, the diagnosis of SMART syndrome was established. CONCLUSION This case series aims to raise awareness among professionals of the importance of training in this pathology, especially in view of the advances in oncological treatments and the expected increase in its incidence.

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