Association of the new atherogenic index non-high-sensitivity C-reactive protein/HDL with significant coronary artery disease in patients with suspected coronary artery disease

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Suspected coronary artery disease (n=203). Intervention: Novel atherogenic index (CRP [mg/dL] x 100 / HDL-C [mg/dL]) vs. Traditional atherogenic indexes (Castelli I, Castelli II, and atherogenic index of plasma [AIP]). Primary outcome: Significant coronary heart disease (CHD) (OR 1.59, 95% CI 1.2-2.1, p=0.001).

Q: What does this research mean for the field?

The non-high-sensitivity C-reactive protein to HDL ratio (CRP×100/HDL) independently predicts significant coronary heart disease and multivessel disease in patients with suspected coronary artery disease. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Victor E. Vallejo-García; Óscar Fabregat‐Andrés; Francisco Javier Ferrer Sargues; Noemí Valtueña‐Gimeno; Dolores Cejalvo‐Lapeña; Guillermo Javier Valls Gumbau; José María Tormos

doi:10.1016/j.rceng.2026.502652

November 1, 2026Revista Clínica Española (English Edition)

Association of the new atherogenic index non-high-sensitivity C-reactive protein/HDL with significant coronary artery disease in patients with suspected coronary artery disease

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Why the study?

Atherogenic indexes stratify cardiovascular risk, motivating evaluation of whether a novel index combining inflammatory and lipidic residual risk parameters is associated with significant CHD.

Is the novel atherogenic index (CRP x 100 / HDL-C) associated with significant coronary heart disease compared with traditional atherogenic indexes in patients with suspected coronary heart disease?

Key Points

To evaluate the association between a novel atherogenic index incorporating inflammatory and lipid residual risk and significant coronary heart disease in patients with suspected disease.
Evaluated N=203 patients (mean age 53.9 ± 7.34 years) presenting with suspected coronary heart disease.
Calculated a new atherogenic index defined as [CRP (mg/dL) × 100] / HDL-C (mg/dL) and compared its performance to Castelli I, Castelli II, and the atherogenic index of plasma.
Significant coronary heart disease was present in 114 patients (55.9%).
The CRP×100/HDL ratio achieved the highest sensitivity and specificity, emerging as the sole predictor of significant coronary heart disease (OR 1.59, 95% CI 1.2–2.1, p=0.001).
The novel ratio also independently predicted multivessel disease (OR 1.45, 95% CI 1.2–1.7, p<0.001).

Study Design

Type

Cross-Sectional (n=203)

Structured PICO

Is the novel atherogenic index (CRP x 100 / HDL-C) associated with significant coronary heart disease compared with traditional atherogenic indexes in patients with suspected coronary heart disease?

P

Population

203 patients with suspected coronary heart disease (mean age 53.9 years), of whom 55.9% had significant coronary heart disease.

E

Exposure

Novel atherogenic index defined as non-high-sensitivity C-reactive protein (CRP in mg/dL) multiplied by 100 divided by HDL-C (mg/dL) (PCRx100/HDL)

C

Comparator

Traditional atherogenic indexes: Castelli I, Castelli II, and atherogenic index of plasma (AIP)

O

Outcome

Significant coronary heart disease (CHD)surrogate

Main Result

Odds Ratio: 1.59 (95% CI 1.2–2.1)

p-value: p=0.001

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Implication

A novel combined inflammatory-lipid index (CRP x 100 / HDL-C) was the sole independent predictor of significant coronary heart disease and multivessel disease among tested atherogenic indices in patients with suspected CAD.

Abstract

INTRODUCTION: Atherosclerosis is the main cause of coronary heart disease (CHD). Atherogenic indexes (AI) are used to stratify cardiovascular risk. The aim of this study is to evaluate the association with significant CHD of a novel AI that includes parameters of both inflammatory residual risk and lipidic residual risk. METHODS: 203 patients with suspicion of coronary heart disease were included. The new AI was established as the ratio between CRP (mg/dL) multiplied by 100, and HDL-C (mg/dL). It was compared with traditional AI Castelli I and II, and atherogenic index of plasma (AIP). RESULTS: The mean age was 53.9±7.34 years. 114 patients (55.9%) had significant CHD. The ratio PCRx100/HDL had the highest values of sensibility and specifity and was the only predictor of CHD with OR 1.59 (CI 95% 1.2-2.1, p = 0.001) and multivessel disease with OR of 1.45 (CI 95% 1.2 - 1.7, p < 0.001). CONCLUSIONS: The new ratio PCRx100/HDL shows the best association with significant CHD.

Discussion

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Cite This Study

Vallejo-García et al. (2026) conducted a cross-sectional in Suspected coronary artery disease (n=203). Novel atherogenic index (CRP [mg/dL] x 100 / HDL-C [mg/dL]) vs. Traditional atherogenic indexes (Castelli I, Castelli II, and atherogenic index of plasma [AIP]) was evaluated on Significant coronary heart disease (CHD) (OR 1.59, 95% CI 1.2-2.1, p=0.001).

synapsesocial.com/papers/6aee01429d87f46bb8e69ec0 https://doi.org/10.1016/j.rceng.2026.502652

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Association of the new atherogenic index non-high-sensitivity C-reactive protein/HDL with significant coronary artery disease in patients with suspected coronary artery disease

Key Points

Study Design

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Association of the new atherogenic index non-high-sensitivity C-reactive protein/HDL with significant coronary artery disease in patients with suspected coronary artery disease

Key Points

Study Design

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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