What question did this study set out to answer?

The study aims to explore the relationship between gastric cancer progression and the risk of heart failure requiring hospitalization.

January 10, 2026Gut and Liver0 citationsOpen Access

Increased Heart Failure Risk with Gastric Cancer Progression: A Nationwide Population-Based Cohort Study

SLSeunghan LeeNew Generation University College MOMi Jin OhSeoul National University BKB. M. Kim

Key Result

The risk of heart failure requiring hospitalization increased with gastric cancer stage, even in young patients without metabolic risk factors.

Key Points

The study aims to explore the relationship between gastric cancer progression and the risk of heart failure requiring hospitalization.
Analyzed nationwide population data of patients with gastric cancer.
Evaluated the correlation between cancer stage and heart failure incidence.
Identified outcomes related to hospitalization for heart failure.
Patients with advanced gastric cancer stages showed a significantly higher risk of heart failure.
Young patients and those without metabolic risk factors also faced increased heart failure risk.
Close monitoring for heart failure development is advised after cancer treatment.

Structured PICO

Does worsening gastric cancer stage increase the risk of heart failure requiring hospitalization in patients with gastric cancer?

Population

202,347 adults (aged ≥30 years) newly diagnosed with gastric cancer between 2012 and 2019, without a prior diagnosis of heart failure, mean age 63.12, 68.0% male, based in Korea.

Intervention

Advanced gastric cancer stages (regional or distant stage based on SEER summary staging)

Comparator

Localized stage gastric cancer

Outcome

New diagnosis of heart failure requiring hospitalizationhard clinical

In patients with gastric cancer, advancing cancer stage is independently associated with a significantly increased risk of incident heart failure requiring hospitalization.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

In patients with gastric cancer, the risk of heart failure requiring hospitalization increased with worsening cancer stage. Even in young patients and those without metabolic risk factors, close monitoring for heart failure development following cancer treatment is essential.

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