Silencing KAT2A inhibits trophoblast pyroptosis and alleviates preeclampsia by downregulating NLRP3 expression.
Does silencing of KAT2A inhibit trophoblast pyroptosis and alleviate preeclampsia?
KAT2A promotes NLRP3-mediated trophoblast pyroptosis via succinylation, identifying it as a potential therapeutic target for preeclampsia.
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Silencing of KAT2A inhibits trophoblast pyroptosis by downregulating NLRP3 expression, thereby alleviating PE. Mechanistically, KAT2A stabilizes NLRP3 by facilitating its succinylation at K21 site. These findings suggest that KAT2A may be a promising target for the treatment of PE.
Huang et al. (Wed,) reported a other. Silencing KAT2A inhibits trophoblast pyroptosis and alleviates preeclampsia by downregulating NLRP3 expression.