What does this research mean for the field?

A case of adamantinoma-like Ewing sarcoma in the nasal cavity exhibited a previously unreported NRAS Q61R mutation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This case report aims to highlight the unique molecular features of adamantinoma-like Ewing sarcoma with an NRAS mutation.

January 10, 2026Virchows Archiv0 citations

Adamantinoma-like Ewing sarcoma with NRAS Q61R mutation—a hitherto unreported mutation in a case from the nasal cavity

BWBingcheng WuNational University Hospital XQXinyi QuNational University Hospital YLYi Ting LaiNational University Hospital

Key Result

A case of adamantinoma-like Ewing sarcoma in the nasal cavity exhibited a previously unreported NRAS Q61R mutation.

Key Points

This case report aims to highlight the unique molecular features of adamantinoma-like Ewing sarcoma with an NRAS mutation.
Description of clinico-pathological features of the case
Analysis of the NRAS Q61R mutation
Comparison with conventional Ewing sarcoma characteristics
Identification of NRAS Q61R mutation as previously unreported in ALES
Observation of distinct morphological and immunohistochemical features in this ALES case
Discussion of the need for further investigations into the mutation's significance

Structured PICO

Population

75-year-old lady with Adamantinoma-like Ewing sarcoma (ALES) in the nasal septum

Outcome

Identification of clinico-pathological features and genetic mutations

Reports a novel NRAS Q61R mutation in a rare case of Adamantinoma-like Ewing sarcoma of the nasal septum.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Adamantinoma-like Ewing sarcoma (ALES) is a rare malignant neoplasm currently classified as a subtype of Ewing sarcoma (ES) and is similarly molecularly defined by a FET-ETS translocation. However, ALES demonstrates some morphologic and immunohistochemical features distinct from conventional ES. In this case report, we present the clinico-pathological features of a case of ALES in the nasal septum of a 75-year-old lady, with a hitherto unreported NRAS Q61R mutation. Further studies are required to investigate the prevalence and clinical significance of the NRAS Q61R mutation in ALES.

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