Primary Ewing′s Sarcoma of the Sinonasal Region: A Rare Clinical Encounter

Ewing's sarcoma (EWS) is a highly aggressive tumor of neuroectodermal origin, rarely occurring in the sinonasal tract, particularly in adults. We report a 27-year-old male with long-standing nasal obstruction, initially misdiagnosed as nasal chondromesenchymal hamartoma. Surgical excision revealed a destructive, vascular sinonasal mass. Histology showed sheets of small round cells within a sclerotic stroma, and immunohistochemistry positivity for CD99, vimentin, cyclin D1, BCL2, and NKX2.2 confirmed EWS. This case underscores the diagnostic difficulty of sinonasal small round cell tumors and the necessity of thorough histopathological and immunohistochemical analysis.