Key result
Rare sinonasal and orbital Ewing's sarcoma in a 24-year-old male requires comprehensive pathological diagnosis.
Why the study?
Ewing's sarcoma rarely occurs in the sinonasal tract, and clinical studies on this localization are limited.
Case Report (n=1)
Highlights a rare case of Ewing's sarcoma in the sinonasal tract with orbital extension.
Answers are grounded in this paper and cite their sources.
May prompt inclusion of Ewing's sarcoma in sinonasal-orbital differentials; leaves open need for larger series on management.
Ewing's sarcoma is a rare and aggressive tumor which classified as peripheral primitive neuroectodermal tumor. It commonly arises in the long bones of the extremities and rarely in the head and neck region. Localization of the sinonasal tract is a rare occurrence thus the number of clinical studies published in the literature are limited. The diagnosis of this tumor requires a histopathological examination, immunohistochemistry and cytogenetic analysis. Ewing's sarcomas are characterized by a CD99 positivity in immunohistochemistry stain and a t(11:22)(q24:q12) translocation in cytogenetic study. The treatment of choice is the multimodality treatment including surgery, radiotherapy and chemotherapy. This is a case report of sinonasal and orbital Ewing's sarcoma in a 24-year-old male patient who presented with a history of right nasal obstruction, right eye pain and periorbital edema.
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Hussain et al. (2019) conducted a case report in Ewing's sarcoma of the sinonasal tract with orbital extension (n=1). Multimodality treatment (surgery, radiotherapy, and chemotherapy) was evaluated. A 24-year-old male presented with a rare case of sinonasal and orbital Ewing's sarcoma, a tumor requiring histopathological, immunohistochemical, and cytogenetic analysis for diagnosis.
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