What question did this study set out to answer?

To investigate the association between atrial fibrillation and outcomes in acute pancreatitis.

January 10, 2026BMC Gastroenterology0 citationsOpen Access

Association between atrial fibrillation and both the in-hospital mortality and disease severity in acute pancreatitis: insights from a multicenter study

Q: What does this research mean for the field?

Atrial fibrillation is independently associated with increased disease severity but does not increase the risk of in-hospital mortality in patients with acute pancreatitis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

HJHonglei JuWannan Medical College SCShuqin CaoWannan Medical College GWGuixiang WangHarbin Engineering University

Key Result

Atrial fibrillation was independently associated with increased disease severity but did not increase the risk of in-hospital mortality in patients with acute pancreatitis.

Key Points

To investigate the association between atrial fibrillation and outcomes in acute pancreatitis.
Conducted a multicenter study assessing patients with acute pancreatitis.
Evaluated the presence of atrial fibrillation and its effects on disease severity and mortality.
Used statistical analysis to determine the relationship between atrial fibrillation and clinical outcomes.
Atrial fibrillation was found to be independently linked to higher disease severity.
No significant increase in in-hospital mortality was observed due to atrial fibrillation.

Structured PICO

Does a history of atrial fibrillation increase in-hospital mortality and disease severity in patients with acute pancreatitis?

Population

3,537 adult inpatients with acute pancreatitis (AP) from three Chinese medical centers. Key exclusions: prior history of pancreatitis, recurrent or chronic pancreatitis, trauma-induced pancreatitis, malignant tumor, under 18 years of age, pregnancy, and incomplete data.

Intervention

History of atrial fibrillation (AF)

Comparator

No history of atrial fibrillation (non-AF group)

Outcome

In-hospital mortality and disease severity (classified as mild acute pancreatitis [MAP] vs. moderate to severe [MSAP] and severe acute pancreatitis [SAP] according to the Revised Atlanta Classification)hard clinical

A history of atrial fibrillation in patients with acute pancreatitis is independently associated with greater disease severity, suggesting these patients may require intensified early monitoring.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Our research indicates that AF is independently associated with the increased disease severity; however, it may not increase the risk of in-hospital mortality in patients with AP.

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