Earlier age at menopause (<46 years) and younger age at first live birth (<22 years) are associated with higher risk of cardiometabolic disease (HR 1.22 and 1.18, respectively).
Are female reproductive factors associated with the risk of incident cardiometabolic disease in women without prior CMD?
Female reproductive factors such as early menopause, short reproductive lifespan, and multiparity are independently associated with an increased risk of incident cardiometabolic disease.
Absolute Event Rate: 0% vs 0%
Background: Cardiometabolic diseases (CMD), including ischemic heart disease, stroke, and type 2 diabetes, have caused an enormous global healthcare burden. Beyond traditional risk factors, female reproductive factors may also be associated with CMD. However, comprehensive evaluations of female reproductive factors related CMD is limited. Methods: A total of 189,411 women with no prior CMD from the UK Biobank cohort from 2007 to 2010 were included and followed until December 2022. Associations between reproductive factors and CMD were analyzed using Cox proportional hazards models with adjustment for potential confounders based on the directed acyclic graph (DAG). Results: During a median follow-up of 13.2 years, 17,251 incident CMD events occurred. Compared to menarche at age 12–13 years, 13 years had a higher risk of CMD (HR 13 y vs 12–13 y: 1.08 1.04–1.13). Earlier age at menopause was related to a higher risk of CMD (HR 4 children: 1.27 1.07–1.52) were associated with higher risk of CMD. Recurrent pregnancy loss was associated with a 39% and 14% higher risk of CMD, respectively. Conclusion: Female reproductive factors are associated with CMD, independent of traditional risk factors. These reproductive factors could inform clinical screening and improve cardiometabolic risk assessment in women.
Wang et al. (Fri,) reported a other. Earlier age at menopause (<46 years) and younger age at first live birth (<22 years) are associated with higher risk of cardiometabolic disease (HR 1.22 and 1.18, respectively).