What question did this study set out to answer?

The aim is to explore the association between the CYP11B2 genetic variant and essential hypertension, as well as the response to antihypertensive treatment.

January 10, 2026Personalized Medicine0 citations

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Association between CYP11B2 rs1799998 genetic variant with essential hypertension and antihypertensive response

Q: What does this research mean for the field?

The CYP11B2 -344C/T variant is associated with a better antihypertensive response to amlodipine, but not with essential hypertension in Jordanians. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

DADalia AbdelrazaqUniversity of Jordan YJYazun JarrarAl-Balqa Applied University HAHussein AlhawariUniversity of Jordan

Key Result

The CYP11B2 -344C/T variant was associated with better antihypertensive response to amlodipine, but not with essential hypertension in Jordanians.

Key Points

The aim is to explore the association between the CYP11B2 genetic variant and essential hypertension, as well as the response to antihypertensive treatment.
Analyzed the association of CYP11B2 -344C/T variant with essential hypertension in Jordanians.
Assessed the response to amlodipine based on the genetic variant.
CYP11B2 -344C/T variant was not linked to essential hypertension in the studied population.
The variant showed a significant association with an improved response to amlodipine.

Structured PICO

Is the CYP11B2 -344C/T variant associated with essential hypertension and amlodipine response in Jordanians?

Population

Jordanians evaluated for essential hypertension and amlodipine response

Intervention

CYP11B2 -344C/T variant (rs1799998)

Outcome

Essential hypertension diagnosis and amlodipine response

The CYP11B2 -344C/T variant may serve as a pharmacogenetic marker for amlodipine response in Jordanian patients with essential hypertension.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

The CYP11B2 -344C/T variant was not associated with EH in Jordanians, but it was associated with amlodipine response. Further studies with larger sample size are needed to validate these findings.

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Association between CYP11B2 rs1799998 genetic variant with essential hypertension and antihypertensive response

Key Result

Key Points

Structured PICO

Main Result

Abstract

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