Increased cardiac infiltration of activated CD3 T-lymphocytes with pro-inflammatory and profibrotic signaling was observed in dilated cardiomyopathy patients.
Transcriptomic analysis reveals an activated, pro-inflammatory, and profibrotic phenotype of cardiac CD3+ T-lymphocytes in dilated cardiomyopathy.
Absolute Event Rate: 0% vs 0%
BACKGROUND: Dilated cardiomyopathy (DCM) is characterized by increased infiltration and activation of the innate immune system, including neutrophils, monocytes/macrophages, and dendritic cells. However, the phenotypic profile of cardiac CD3 METHODS: We studied phenotypic signatures of T-cell subsets by analyzing publicly available single-cell and single-nuclear transcriptomic datasets from control and failing hearts of DCM patients. RESULTS: Our analysis revealed increased cardiac infiltration of CD3 CONCLUSION: Here we demonstrate for the first time, an "activated phenotype" with increased pro-inflammatory and profibrotic signaling in cardiac CD3
Angelotti et al. (Wed,) reported a other. Increased cardiac infiltration of activated CD3 T-lymphocytes with pro-inflammatory and profibrotic signaling was observed in dilated cardiomyopathy patients.
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