Key result
The APOE ε4 allele was not associated with overall vascular brain injury incidence in American Indians (HR 2.84; 95% CI 0.17-48.59).
Why the study?
Does the presence of the APOE ε4 allele increase longitudinal vascular brain injury in American Indians?
Cohort
Yes
Does the presence of the APOE ε4 allele increase longitudinal vascular brain injury in American Indians?
Answers are grounded in this paper and cite their sources.
The APOE ε4 allele does not appear to be significantly associated with incident vascular brain injury over time in American Indians.
Background and Objective: ε4 carriers exhibited greater longitudinal changes in WMH or if the previously reported null effect from cross-sectional findings extended over time in American Indians. Methods: genotype was determined through serum analysis and dichotomized based on the presence of the ε4 allele. Covariates included age, sex, education, hypertension, diabetes, stroke history, body mass index, low-density lipoprotein cholesterol, and study site. We used Poisson regression for binary VBI outcomes, linear mixed-effects models to assess longitudinal WMH changes, and Cox regression to analyze incident VBI. Results: ε4 was not associated with overall VBI incidence in fully adjusted models (HR = 2.84, 95% CI: 0.17-48.59). Discussion: ε4 on brain aging in American Indians is required to validate these findings.
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Hayes et al. (2025) conducted a cohort in Vascular Brain Injury. APOE ε4 allele vs. Absence of the ε4 allele was evaluated on Overall VBI incidence (HR 2.84, 95% CI 0.17-48.59). The APOE ε4 allele was not associated with overall vascular brain injury incidence in American Indians (HR 2.84; 95% CI 0.17-48.59).
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