Why the study?
The study investigated the effects of APOE ε4 and its interactions with sociodemographic characteristics on cognitive measures in South Asians from LASI-DAD.
Does APOE ε4 carrier status reduce cognitive function in older South Asian adults?
Does APOE ε4 carrier status reduce cognitive function in older South Asian adults?
APOE ε4 is associated with lower cognitive function in older South Asians, with stronger effects in females and those over 68 years of age.
May support targeted cognitive monitoring in older female South Asian APOE ε4 carriers; leaves open need for longitudinal confirmation before clinical use.
BACKGROUND We investigated effects of APOE ε4 and its interactions with sociodemographic characteristics on cognitive measures in 2,563 South Asians from the Diagnostic Assessment of Dementia for the Longitudinal Aging Study of India (LASI-DAD). METHODS Linear regression models were used to assess the association between APOE ε4 and global- and domain-specific cognitive function. Effect modification by age, sex, and education were explored using cross-product interaction terms and subgroup analyses. RESULTS APOE ε4 was inversely associated with most cognitive measures. This association was stronger in the older age group (age >68) for general cognitive function, orientation, and language/fluency, as well as in females for memory and language/fluency. Interaction between APOE ε4 and education was mostly nonsignificant. DISCUSSION APOE ε4 is associated with lower cognitive function in South Asians from India, with a more pronounced impact observed in females and older individuals.
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Wang et al. (2024) studied this question.
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