Reduced Effect of APOE4 on White Matter Microstructure in an American Indian Community

Key Points

• This study investigates the relationship between the APOE4 allele and white matter microstructure in an American Indian community.
• Examined white matter microstructure among Elders in the American Indian community
• Focus on those carrying the APOE4 allele
• Utilized neuroimaging techniques to assess brain health
• APOE4's effect on white matter microstructure was significantly reduced in the American Indian population examined
• Findings suggest a unique ancestry-dependent relationship affecting Alzheimer disease risk
• Results indicate that traditional risks associated with APOE4 may not directly apply to this community