Key result
The APOEɛ4 allele was associated with significantly lower performance in global cognition, verbal memory, executive functions, and visuospatial abilities in Panamanian older adults.
Why the study?
APOEɛ4 is the strongest genetic risk factor for sporadic Alzheimer disease, but inconsistencies have arisen in studies involving Hispanics.
Does the presence of the APOEɛ4 allele affect cognitive function in Panamanian older adults?
Observational
Does the presence of the APOEɛ4 allele affect cognitive function in Panamanian older adults?
The APOEɛ4 allele is associated with impairment across multiple cognitive domains in elderly Hispanics, regardless of clinical diagnosis.
APOEɛ4 carriage was associated with multi-domain cognitive deficits in Panamanian elders; extends prior links to Hispanics but leaves causality and practice implications open.
Apolipoprotein ɛ4 allele (APOEɛ4) is the strongest genetic risk factor for sporadic Alzheimer's disease (AD), but inconsistencies have arisen in studies with Hispanics. The objective of this study was to explore APOEɛ4 expression and cognitive function in a sample of Panamanian older adults, including healthy controls, mild cognitive impairment, and AD. Participants with at least one copy of APOEɛ4 had a significantly lower performance in global cognition, verbal memory, executive functions, visuospatial abilities, regardless of diagnosis. The present study contributes to the understanding of the association of APOEɛ4 and impairment in specific cognitive domains in elderly Hispanics.
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Oviedo et al. (2020) conducted an observational in Alzheimer's disease and mild cognitive impairment. Apolipoprotein ɛ4 allele (APOEɛ4) vs. Absence of APOEɛ4 allele was evaluated on Cognitive function across multiple domains. The APOEɛ4 allele was associated with significantly lower performance in global cognition, verbal memory, executive functions, and visuospatial abilities in Panamanian older adults.
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