Association of cognitive impairment and APOE ε4 with Centiloids in Hispanic and non‐Hispanic White cohorts

INTRODUCTION: Weak associations of apolipoprotein E (APOE) ε4 with cognitive impairment have been reported in Hispanic cohorts. To determine if APOE ε4 associates with brain amyloid load differently in Hispanic and non-Hispanic White (NHW) cohorts, we analyzed reported Centiloid values from studies that conducted amyloid positron emission tomography. METHODS: This meta-analysis included 17,017 participants (8.4% Hispanic) from five source studies. Analysis of covariance and logistic regression models adjusting for age, sex, education, and cognitive score were applied. RESULTS: Although cognitive impairment and APOE ε4 were associated with higher Centiloids in both Hispanic and NHW cohorts, cognitively impaired and APOE ε4 positive Hispanic participants had lower Centiloids than NHW participants with the same conditions. DISCUSSION: APOE ε4 may have a weaker influence on brain amyloid load in Hispanic cohorts. Further comparative analyses are necessary for Alzheimer's disease anti-amyloid treatments to be widely applicable to Hispanic populations.