What does this research mean for the field?

Elevated atherogenic index of plasma (AIP) is associated with increased cognitive impairment risk among hypertensive adults. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To explore the association between elevated atherogenic index of plasma (AIP) and cognitive impairment risk in hypertensive adults.

January 10, 2026Aging Clinical and Experimental Research0 citationsOpen Access

Atherogenic index of plasma and cognitive impairment risk among hypertensive adults: evidence from a nationwide cohort study

WBWeimin BaiHenan University BFBing FengPeople's Liberation Army 401 Hospital YLY. LiTianjin First Center Hospital

Key Result

Elevated atherogenic index of plasma (AIP) was associated with increased cognitive impairment risk among hypertensive adults.

Key Points

To explore the association between elevated atherogenic index of plasma (AIP) and cognitive impairment risk in hypertensive adults.
Utilized a nationwide cohort design
Examined middle-aged and older adults with hypertension
Assessed cognitive function and AIP levels through standardized tests and measurements
Elevated AIP linked to higher risk of cognitive impairment
Independently associated results suggest clinical relevance
Highlights potential for AIP as an early risk identification tool

Structured PICO

Does an elevated atherogenic index of plasma (AIP) increase the risk of cognitive impairment in middle-aged and older adults with hypertension?

Population

3,739 middle-aged and older adults (aged ≥45 years) with hypertension from the China Health and Retirement Longitudinal Study (CHARLS), mean age 60.5, 50.0% female. Excluded: history of memory disorders or mental health conditions.

Intervention

Higher atherogenic index of plasma (AIP) quartiles (Q2-Q4), calculated as Log10(TG/HDL-C)

Comparator

Lowest atherogenic index of plasma (AIP) quartile (Q1, <0.174)

Outcome

Cognitive impairment (defined as a cognitive function score at least 1.0 standard deviation below the mean) at 2018 follow-up

Elevated atherogenic index of plasma is independently associated with an increased risk of cognitive impairment in hypertensive adults, suggesting its potential as a simple biomarker for early risk stratification.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

Elevated AIP was independently associated with an increased risk of cognitive impairment among middle-aged and older adults with hypertension, suggesting its potential as a practical biomarker for early identification of cognitive risk in this high-risk population.

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