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November 30, 2025CureusOpen Access

The Effects of Sodium-Glucose Co-transporter 2 Inhibitors on Cardiovascular Outcomes in Heart Failure: A Systematic Review and Meta-Analysis

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Authors

AMAkshay MaharajSBSajay BidhesiDGDiya Grover

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Overview

Systematic review and meta-analysis reveals reduced mortality and rehospitalization with SGLT2 inhibitors in heart failure, highlighting their broad cardioprotective benefits.

Key Points

  • To evaluate the clinical outcomes of SGLT2 inhibitors in heart failure, focusing on mortality rates, hospitalizations, renal function, and left ventricular ejection fraction.
  • Systematically reviewed and meta-analyzed 9 randomized controlled trials evaluating SGLT2 inhibitor therapy in heart failure.
  • Calculated pooled risk ratios (RR) using a random-effects model alongside heterogeneity analyses for mortality and heart failure rehospitalization.
  • SGLT2 inhibitors were associated with a 20% relative reduction in mortality (RR = 0.80).
  • Treatment led to a 24% relative risk reduction in rehospitalization secondary to heart failure (RR = 0.76).

Cite This Study

Maharaj et al. (2025) studied this question.

synapsesocial.com/papers/6965117fb22366569afe4459https://doi.org/10.7759/cureus.98140
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effectiveness of Sodium-Glucose Co-Transporter 2 (SGLT2) Inhibitors in Reducing Cardiovascular Mortality in Heart Failure: Systematic Review and Meta-Analysis2024
  2. 2Cardiovascular outcomes and safety assessment of SGLT2i on heart failure patients: a systematic review and meta-analysis2025 · 1 citations
  3. 3Sodium-Glucose Cotransporter-2 (SGLT-2) Inhibitors in Heart Failure: An Umbrella Review2023 · 8 citations
  4. 4Glucose cotransporter-2 inhibitors on mortality and hospitalization in heart failure patients: a comprehensive meta-analysis2026 · 1 citations
  5. 5Effectiveness of SGLT2 inhibitor therapy in treatment of Heart failure: A Meta-Analysis2023