Bis(Cyclooctadiene)Nickel(0)-Catalyzed Exhaustive C(sp2)-X and C(sp3)-F Hydrodehalogenation and Deuterodefluorination of Pyridines and Arenes with Broad Substrate Scope | Synapse
January 14, 2026Inorganic Chemistry Frontiers0 citations
Bis(Cyclooctadiene)Nickel(0)-Catalyzed Exhaustive C(sp2)-X and C(sp3)-F Hydrodehalogenation and Deuterodefluorination of Pyridines and Arenes with Broad Substrate Scope
The research aims to explore the hydrodehalogenation of pyridines and arenes using Nickel(0) catalysis.
Cal Catalysis using [Ni(COD)2] and NH3BH3
Focus on hydrodehalogenation of C(sp2)-X and C(sp3)-F
Worked with CF3 groups in pyridines and various C(sp2)-X bonds
Successful hydrodehalogenation of CF3 in pyridines
Broad substrate scope with C(sp2)-X and C(sp3)-F bonds
High efficiency and selectivity observed in reactions
Abstract
The exhaustive hydrodehalogenation (HDH) of CF3 groups in pyridines and of C(sp2)-X (X = F, Cl, Br, I) bonds in pyridines and arenes was catalyzed by Ni(COD)2 employing NH3BH3 in...