What question did this study set out to answer?

Evaluate factors associated with treatment failure and mortality in patients with periprosthetic infections.

January 14, 2026Open Forum Infectious Diseases0 citationsOpen Access

P-84. Periprosthetic infections: Treatment failure and mortality

GTGustavo A Castro TorresCentro de Educación Médica e Investigaciones Clínicas Norberto Quirno ETElena TemporitiCentro de Educación Médica e Investigaciones Clínicas Norberto Quirno PBPablo BonvehíCentro de Educación Médica e Investigaciones Clínicas Norberto Quirno

Key Points

Evaluate factors associated with treatment failure and mortality in patients with periprosthetic infections.
Retrospective observational analytical study of patients diagnosed with PI of the hip and knee from 2014 to 2024.
Assessment of demographic variables, prosthesis type, clinical data, isolated microorganisms, and treatment approaches.
Analysis of factors associated with treatment failure based on suppressive therapy, second-look surgery, and mortality.
Utilization of Chi-square tests for dichotomous variables and logistic regression for mortality-associated factors.
Of 67 patients, 77% had hip PI, and the median age was 74 years.
One-year mortality was 18%, linked to factors such as fracture indication and multidrug-resistant infections.
Treatment failure correlated with recurrent prosthetic loosening, dislocation, early infection, and DAIR procedures.

Abstract

Abstract Background Periprosthetic infections (PI) lead to increased morbidity, mortality, and healthcare costs. There are few data available on the various factors associated with treatment failure and mortality. The objective was to evaluate these factors in a specific patient cohort. Methods Retrospective observational analytical study of patients diagnosed with PI of the hip and knee at a university hospital between 2014 and 2024. Demographic variables, prosthesis type and indication, clinical data, isolated microorganisms, and treatment were assessed. Factors associated with treatment failure were defined as use of suppressive therapy (UST), second-look surgery (SLS), and mortality within one year of follow-up. Measures of association were analyzed, including the Chi-square test (dichotomous variables) and Student's t-test (quantitative variables). A logistic regression model was used to determine mortality-associated factors. Results Of 67 patients included in the study, 77% had hip PI and 23% knee PI. 34% were men, with a median age of 74 years (IQR 66–81). Ninety-five percent of the patients underwent surgery, 69% DAIR (debridement, antibiotics, and implant retention), and 21% two-stage implant replacement. Comorbidities included 13% diabetes, 22.3% immunosuppression, and 67% cardiovascular disease. Sixty-four percent had early PI ( 3 months) and 60% monomicrobial PI, with Staphylococcus aureus being the most frequently isolated microorganism (35%). No association was found with the need for suppressive therapy. SLS was associated with loosening of a previous prosthesis (p=0.04), recurrent prosthetic dislocation (p=0.04), early infection (p=0.029), and DAIR (p=0.004). One-year mortality was 18%. Multivariate analysis revealed that it was associated with fracture as an indication for prosthesis replacement (OR 7.21, p=0.002) and multidrug-resistant gram-negative bacilli (MDR-GNB) infection (OR 25.5, p=0.004). Conclusion In our cohort of PI patients, treatment failure was associated with recurrent prosthetic loosening and dislocation, early infection, and DAIR, while mortality was associated with fracture as an indication for joint replacement and MDR-GNB infection. Disclosures All Authors: No reported disclosures

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