What question did this study set out to answer?

To evaluate long-term mortality and assess the impact of causative pathogens in periprosthetic joint infections after total hip arthroplasty.

January 18, 2026Open Access

Increased long-term mortality of patients with prosthetic joint infection after primary total hip arthroplasty - a large observational cohort study.

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Observational cohort study evaluates long-term mortality in patients with joint infection post hip surgery, indicating significant health risks.

To evaluate long-term mortality and assess the impact of causative pathogens in periprosthetic joint infections after total hip arthroplasty.
Conducted a retrospective nationwide cohort study using the Swiss Joint Registry data from 2012 to 2022.
Included adults undergoing total hip arthroplasty with follow-up for up to 10 years.
Used Gompertz regression to estimate adjusted hazard ratios while controlling for sex, age, BMI, and ASA class.
Of the 215,678 patients, 89,709 met the inclusion criteria for analysis.
Patients with prosthetic joint infection had a significant increase in mortality hazard (aHR 2.15), while those who underwent aseptic revision did not (aHR 0.92).
Specific pathogens linked to increased mortality included Enterobacterales (aHR 3.17) and Staphylococcus aureus (aHR 2.32).
Cutibacterium acnes showed a high mortality hazard (aHR 2.31).

Widmer et al. (2026) studied this question.

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Observational cohort study evaluates long-term mortality in patients with joint infection post hip surgery, indicating significant health risks.