Development of self-assembled peptide hydrogels containing matrix-metalloproteinase degradable motifs for 3D lung cancer models

Burcu Sırma Tarım; Sedef Tamburacı; Ayben Top

doi:10.1039/d5sm00890e

January 1, 2026Soft Matter

Development of self-assembled peptide hydrogels containing matrix-metalloproteinase degradable motifs for 3D lung cancer models

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Key Points

To develop peptide hydrogels for creating 3D lung cancer models that mimic the tumor environment.
Utilized peptide hydrogelators with MMP-2 degradation properties
Encapsulated A549 cells within the hydrogels
Created 3D models for testing anticancer efficacy
Successful encapsulation of A549 lung cancer cells
Development of 3D models that can be used for anticancer drug testing
Hydrogels show degradation properties specific to MMP-2

Implication

Novel peptide hydrogels demonstrate matrix-metalloproteinase properties for 3D lung cancer models, suggesting potential in drug testing.

Abstract

Novel peptide hydrogelators with MMP-2 degradation properties were utilized to encapsulate A549 cells, thereby creating 3D lung cancer models for testing anticancer drugs.

Discussion

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Cite This Study

Tarım et al. (2026) studied this question.

synapsesocial.com/papers/6966f2fb13bf7a6f02c005d8 https://doi.org/10.1039/d5sm00890e

View Full Paper

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Development of self-assembled peptide hydrogels containing matrix-metalloproteinase degradable motifs for 3D lung cancer models

Key Points

Implication

Abstract

Discussion

Cite This Study

Development of self-assembled peptide hydrogels containing matrix-metalloproteinase degradable motifs for 3D lung cancer models

Key Points

Implication

Abstract

Discussion

Cite This Study

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