What type of study is this?

This is a Case Report study (also classified as: Literature Review).

What question did this study set out to answer?

To discuss the diagnostic issues related to elevated alpha-fetoprotein in patients with colorectal adenocarcinoma and liver metastases.

January 14, 2026Diagnosis

Raised alpha fetoprotein in cirrhotic liver with colorectal liver metastasis mimicking hepatocellular carcinoma: case report and review of literature

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Authors

AAAboje AdugbaSultan Qaboos University Hospital DADominic Obotu AyegbaSultan Qaboos University Hospital SMSamah MansourWestern University

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Implication

Case report reveals diagnostic challenges of elevated alpha-fetoprotein in colorectal adenocarcinoma with liver metastases, suggesting careful histological evaluation is essential.

Key Points

To discuss the diagnostic issues related to elevated alpha-fetoprotein in patients with colorectal adenocarcinoma and liver metastases.
Case report of a 58-year-old man with chronic hepatitis B and cirrhosis.
Evaluation of imaging studies revealing hepatic lesions suggestive of hepatocellular carcinoma.
Histological confirmation via core biopsy of liver lesions to determine cancer origin.
Initial diagnosis favored hepatocellular carcinoma based on imaging and elevated alpha-fetoprotein levels.
Final diagnosis confirmed poorly differentiated colorectal adenocarcinoma upon biopsy.
The case emphasizes the rarity of colorectal adenocarcinoma producing alpha-fetoprotein in patients with liver cirrhosis.

Cite This Study

Adugba et al. (2026) studied this question.

synapsesocial.com/papers/6966f2fb13bf7a6f02c00699 https://doi.org/10.1515/dx-2025-0143

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Implication

Case report reveals diagnostic challenges of elevated alpha-fetoprotein in colorectal adenocarcinoma with liver metastases, suggesting careful histological evaluation is essential.

Raised alpha fetoprotein in cirrhotic liver with colorectal liver metastasis mimicking hepatocellular carcinoma: case report and review of literature

Discussion

Member takes

Implication

Key Points

Cite This Study

Raised alpha fetoprotein in cirrhotic liver with colorectal liver metastasis mimicking hepatocellular carcinoma: case report and review of literature

Discussion

Member takes

Implication

Key Points

Cite This Study

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