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June 20, 2026American Journal of Case ReportsOpen Access

Solitary Peritoneal Metastasis of AFP-Negative Hepatocellular Carcinoma in a 65-Year-Old Man with a History of Lung Adenocarcinoma: A Case Report

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Authors

XZXie ZJHJie HuangKFKailong Fu

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Overview

Case report reveals challenges in diagnosing AFP-negative HCC metastasis in a male with lung adenocarcinoma.

Key Points

  • To highlight the diagnostic challenges of AFP-negative hepatocellular carcinoma with peritoneal metastasis in a patient with a complex cancer history.
  • Detailed clinical examination and history-taking in a 65-year-old male.
  • Laboratory testing for serum AFP and CA125, along with imaging studies.
  • Surgical resection followed by histopathological evaluation with immunohistochemistry.
  • The patient had normal serum AFP levels and elevated CA125; imaging confirmed a solitary peritoneal mass.
  • Histopathology showed the tumor was hepatocellular in origin with negative AFP staining.
  • Postoperative recovery was uneventful with no recurrence at the 3-month follow-up.

Cite This Study

Z et al. (2026) studied this question.

synapsesocial.com/papers/6a362e62db0793dc1a53611bhttps://doi.org/10.12659/ajcr.953374
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Also Consider

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  4. 4Primary Hepatoid Adenocarcinoma of the Lung With Signet Ring Cell Differentiation and Widespread Osseous Metastases: A Case Report2026
  5. 5Hepatoid Adenocarcinoma of the Stomach with Liver and Pulmonary Metastases: A Case Report and Literature Review2024 · 1 citations