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January 14, 2026Open Forum Infectious DiseasesOpen Access

P-947. The Impact of Physician-Driven Antimicrobial Stewardship Intervention with Education, Post-Prescription Review and Feedback on Empirical Antimicrobials Initiated in the Medical Intensive Care Unit

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Authors

JSJ SelvaKumarRagas Dental College & HospitalJSJerlin Prasanna Victor SelvarajRagas Dental College & HospitalKKKeerthana KarthikeyanRagas Dental College & Hospital

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Implication

Cohort study shows reduced days of therapy and inappropriate use in ICU patients, indicating effective stewardship intervention.

Key Points

  • To assess the effectiveness of a physician-driven antimicrobial stewardship program in a medical intensive care unit.
  • Prospective cohort study conducted at a tertiary care hospital over 10 months.
  • Included patients aged ≥ 18 years receiving antimicrobials for 48 hours or more in the ICU.
  • Three phases: baseline observation, education phase, and intervention with post-prescription feedback.
  • Days of therapy per 1000 patient days decreased from 2258.9 to 1672 (P < 0.001).
  • Inappropriate antimicrobial use reduced from 61% to 38.2% (P = 0.14).
  • Unnecessary double coverage decreased from 54.3% to 26.4% (P = 0.007) and inappropriate choice from 38.1% to 10.9% (P < 0.001).

Cite This Study

SelvaKumar et al. (2026) studied this question.

synapsesocial.com/papers/6966f2fb13bf7a6f02c0072ahttps://doi.org/10.1093/ofid/ofaf695.1150
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of Antimicrobial stewardship implementation in an Intensive Care Unit in Central India – A Microbiologist-Intensivist driven initiative2026
  2. 2Multidisciplinary Antimicrobial Stewardship Program in an Indian ICU: A Time-Series Analysis of Diagnostic Practices and Antibiotic Use2026
  3. 3Optimizing antimicrobial drug utilization through antimicrobial stewardship programme in a tertiary care referral hospital in south India2024
  4. 4Impact of Pharmacist‐Led Antimicrobial Stewardship on Antibiotic Use in Intensive Care: A Prospective Audit and Feedback Approach2026
  5. 5IMPACT OF AN ANTIBIOTIC STEWARDSHIP INTERVENTION ON ANTIBIOTIC USE AND HEALTH-CARE-ASSOCIATED INFECTION RATES2025