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January 14, 2026Hypertension

Efficacy and Safety of Treatment With Low Doses of Spironolactone in Patients With Primary Aldosteronism: A Retrospective Observational Study in a Tertiary Center

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Authors

ESElisa SconfienzaJRJulien RianchoNGNicole Gebara

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Overview

Retrospective study finds low-dose spironolactone effectively controls blood pressure in primary aldosteronism, highlighting lower adverse effects and improved adherence.

Key Points

  • Evaluate the impact of low and high doses of spironolactone on blood pressure control, potassium levels, and adverse effects in primary aldosteronism.
  • Retrospective analysis of 394 patients with primary aldosteronism
  • Comparison of effects between patients treated with doses ≤50 mg and >50 mg of spironolactone
  • Assessment of adverse effects, blood pressure control, potassium and renin levels.
  • 128 patients experienced adverse effects, more common in men (44.7%) versus women (15.7%)
  • Gynecomastia and sexual dysfunction were the most frequently reported adverse effects
  • No significant differences in blood pressure control or potassium levels between dose groups.

Cite This Study

Sconfienza et al. (2026) studied this question.

synapsesocial.com/papers/6966f32713bf7a6f02c00f14https://doi.org/10.1161/hypertensionaha.125.24881
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