February 19, 2007HypertensionOpen Access

Effect of Spironolactone on Blood Pressure in Subjects With Resistant Hypertension

View Full Paper

Ask AI

Bookmark

Why the study?

Does spironolactone reduce blood pressure in patients with resistant hypertension?

Population

1,411 participants from the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm with…

Design

Cohort

Follow-up

median 1.3 years

Authors

NCNeil ChapmanImperial College Healthcare NHS Trust JDJoanna DobsonHiroshima University SWSarah L WilsonWexham Park Hospital

Discussion

Member takes

Implication

May support spironolactone as fourth-line therapy in resistant hypertension; hypothesis-generating pending randomized confirmation.

Structured PICO

Does spironolactone reduce blood pressure in patients with resistant hypertension?

Population

1,411 participants from the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm with uncontrolled blood pressure, mean age 63 years, 77% men, 40% with diabetes.

Intervention

Spironolactone (median dose 25 mg) added to a mean of 2.9 other antihypertensive drugs for a median duration of 1.3 years.

Outcome

Change in blood pressure during spironolactone therapysurrogate

Spironolactone effectively lowers blood pressure when added as a fourth-line agent in patients with resistant hypertension.

Limitations

nonrandomized
not placebo controlled

Cite This Study

Chapman et al. (2007) studied this question.

synapsesocial.com/papers/6a0fcbb301be78fe81600c19 https://doi.org/10.1161/01.hyp.0000259805.18468.8c

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Effect of Spironolactone on Blood Pressure in Subjects With Resistant Hypertension

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Effect of Spironolactone on Blood Pressure in Subjects With Resistant Hypertension

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

Also Consider