The role of spironolactone in the treatment of patients with refractory hypertension
Why the study?
Does spironolactone improve blood pressure control in patients with refractory hypertension?
Population
25 patients with refractory hypertension referred to a single medical clinic.
Design
Cohort
Follow-up
3 months
Authors
Discussion
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Member takes
Implication
Spironolactone was associated with BP reduction in refractory hypertension; hypothesis-generating and should not yet change practice.
Structured PICO
Does spironolactone improve blood pressure control in patients with refractory hypertension?
P
Population
25 patients with refractory hypertension (hypertension ≥6 months without apparent cause, clinical and mean 24-h ambulatory BP >140/90 mm Hg despite treatment with at least two antihypertensive drugs, no prior spironolactone, no renal insufficiency) referred to a single medical clinic.
I
Intervention
Spironolactone 1 mg/kg/day added to previous antihypertensive regimen (with any angiotensin converting enzyme inhibitor suppressed).
O
Outcome
Blood pressure control (clinical BP < 140/90 mm Hg and ambulatory BP monitoring) at 1 month.surrogate
The addition of spironolactone significantly reduces blood pressure and the number of required antihypertensive medications in patients with refractory hypertension.
Cite This Study
Ouzan et al. (2002) studied this question.