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January 14, 2026Open Forum Infectious DiseasesOpen Access

Protective Role of Outer Membrane Vesicles Released by Carbapenemase-Producing Klebsiella pneumoniae Clinical Isolates Against Carbapenems and Cefiderocol

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Authors

AGAna M GonzálezCLCarolina LópezVQValeria E Quiroz

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Overview

Findings reveal that outer membrane vesicles from carbapenemase-producing strains improve survival against carbapenems and cefiderocol, indicating a novel resistance mechanism.

Key Points

  • This research aims to investigate the role of outer membrane vesicles in protecting carbapenem-resistant Klebsiella pneumoniae against antibiotics.
  • Isolated outer membrane vesicles from three carbapenemase-producing clinical strains in Chile.
  • Evaluated presence of NDM and KPC carbapenemases via Western blot and enzymatic activity with nitrocefin.
  • Assessed protective roles of OMVs using growth kinetics of susceptible strains exposed to imipenem and cefiderocol.
  • OMVs were purified from all clinical isolates with high levels of NDM detected.
  • Co-incubation of susceptible strains with NDM-containing OMVs showed enhanced growth under antibiotic pressures.
  • NDM-7 OMVs provided greater protection than NDM-5 against increasing cefiderocol concentrations.

Cite This Study

González et al. (2026) studied this question.

synapsesocial.com/papers/6966f33b13bf7a6f02c011d9https://doi.org/10.1093/ofid/ofaf695.197
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1P-1281. Genomic and Transcriptional Adaptations in a Spontaneous Cefiderocol-Resistant Klebsiella pneumoniae KPC-Producing Mutant Isolate2026 · 1 citations
  2. 2P-1197. NDM-5 and Siderophore Receptor Mutations Drive High Level Cefiderocol Resistance in Klebsiella pneumoniae: A Case Series2026
  3. 3Occurrence of KPC-71 or the presence of NDM combined with a high expression of bla SHV contributes to low-level cefiderocol resistance in carbapenem-resistant Klebsiella pneumoniae in China2025 · 2 citations
  4. 4Spontaneous Emergence of Cefiderocol Resistance in Klebsiella pneumoniae KPC-163: Genomic and Transcriptomic Insights2025 · 2 citations
  5. 5Proteomic alterations in outer membrane vesicles of carbapenem-resistant Klebsiella pneumoniae isolated from sepsis patients2026 · 1 citations