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January 14, 2026Archives of Microbiology

Assessing off-target effects in CRISPR/Cas9: challenges and strategies for precision DNA editing

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Authors

ABAbdul BasitJZJianzhong ZhuWZWanglong Zheng

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Overview

Exploring off-target effects in gene editing, highlighting strategies for safety in genomic modifications.

Key Points

  • This research aims to assess off-target effects in CRISPR/Cas9 and identify strategies to enhance gene editing safety.
  • Review of literature on off-target effects in CRISPR/Cas9
  • Analysis of detection techniques and prediction limitations
  • Discussion on guide RNA design and computational prediction tools
  • Case study evaluation of successful off-target reduction
  • Comparative analysis of Cas9, Cas12, and Cas13 systems
  • Identified challenges in predicting off-target effects
  • Highlighted effective strategies for minimizing unintended genetic modifications
  • Presented successful case studies demonstrating reduced off-target activity
  • Compared different CRISPR systems on their specificity and action mechanisms

Cite This Study

Basit et al. (2026) studied this question.

synapsesocial.com/papers/6966f5183603a7c209c0e1bdhttps://doi.org/10.1007/s00203-025-04687-4
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