What question did this study set out to answer?

The aim is to establish data-driven ferritin decision limits that better correlate with hemoglobin recovery in blood donors.

Real-world big data to define iron deficiency decision limits: implications for cardiovascular health monitoring

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Analysis defines ferritin limits for hemoglobin recovery in blood donors, suggesting refined thresholds for cardiovascular health.

The aim is to establish data-driven ferritin decision limits that better correlate with hemoglobin recovery in blood donors.
Analyzed donor data from the Dutch national blood service covering 2017-2022
Included data from 196,595 whole blood donations
Modeled the relationship between log10 ferritin and hemoglobin change using segmented linear regression
Estimated changepoints via maximum likelihood with bootstrapping for confidence intervals
Identified a linear association between hemoglobin change and ferritin levels
Determined that ferritin levels below 30.7 ng/mL limit hemoglobin recovery in males
Found that the threshold for females is 26.3 ng/mL, differing from current WHO recommendations
Caution advised in generalizing these findings due to limited standardization

Meulenbeld et al. (2026) studied this question.

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