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June 20, 2026TransfusionOpen Access

A ferritin prediction model to determine individual blood donation frequencies

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Authors

MPMart PothastYPYared PaalvastKHKatja van den Hurk

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Overview

Randomized trial predicts optimal donation frequencies using ferritin and donor metrics, suggesting improved health management.

Key Points

  • This research aims to create a model that predicts ferritin levels to optimize blood donation intervals for donors.
  • Developed a physiology-informed model using baseline ferritin, hemoglobin, and donor metrics.
  • Validated predictions with data from donation records in the Netherlands post-2021.
  • Analyzed the effect of weight and baseline ferritin on predicted levels after multiple donations.
  • The model accurately predicted ferritin levels after five donations, with 71% predictions within measurement uncertainty.
  • Average predictions slightly underestimated actual levels, varying with sex and age.
  • Optimal donation frequency tables were generated based on baseline ferritin and weight influence.

Cite This Study

Pothast et al. (2026) studied this question.

synapsesocial.com/papers/6a363274db0793dc1a5391e7https://doi.org/10.1111/trf.70303
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Blood donor populations reveal a clear association between ferritin and change in haemoglobin levels2025
  2. 2Real-world big data to define iron deficiency decision limits: implications for cardiovascular health monitoring2026
  3. 3Effectiveness of Ferritin-guided Donation Intervals in Blood Donors: results of the Stepped Wedge Cluster-randomised FIND’EM Trial2023
  4. 4Menstrual blood loss is an independent determinant of hemoglobin and ferritin levels in premenopausal blood donors2024 · 16 citations
  5. 5Evaluating utility of routine ferritin testing in blood donors: A hospital‐based blood donor centre experience2024 · 1 citations