Phenotypic age acceleration and omega-6/omega-3 PUFA ratio in dynamic atrial fibrillation–heart failure transitions: a multistate analysis

Key Result

Higher PhenoAgeAccel and ω-6/ω-3 PUFA ratios independently increased the risks of transitions from atrial fibrillation to heart failure.

Key Points

• This research aims to explore how phenotypic age acceleration and ω-6/ω-3 PUFA ratios relate to transitions between atrial fibrillation and heart failure.
• Conducted a multistate analysis to examine transitions between atrial fibrillation and heart failure.
• Evaluated associations using measures of phenotypic age acceleration and fatty acid ratios.
• Analyzed pathways related to lipids and inflammation to understand underlying mechanisms.
• Found that higher phenotypic age acceleration is linked to increased risks of transitioning from atrial fibrillation to heart failure.
• Observed that higher ω-6/ω-3 PUFA ratios are also associated with elevated risks of AF-HF transitions.
• Identified lipid and inflammatory pathways as partial explanations for these associations.