Demonstrates how local effects and DNA damage predict cell survival, suggesting improved modeling approaches.
The overkill effect was reflected in the models based on LEM and DDM by employing threshold local dose and threshold number of DSBs in sub-volumes, respectively. Results suggest that the number of sub-volumes impacted with DSBs rather than the DSB multiplicity within individual sub-volumes would be better parameter to predict cell killing effect, which complies with the GLOBLE model.
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Shqair et al. (2026) studied this question.
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