Key result
Cardiac resynchronization therapy reduced moderate or severe mitral regurgitation to non-significant levels in one-third of patients but its persistence worsened clinical outcomes.
Why the study?
Does the persistence of secondary mitral regurgitation after cardiac resynchronization therapy affect clinical outcomes, arrhythmic events, and reverse remodelling?
Does the persistence of secondary mitral regurgitation after cardiac resynchronization therapy affect clinical outcomes, arrhythmic events, and reverse remodelling?
While CRT can reduce secondary mitral regurgitation in about a third of patients, persistent MR is a marker for worse clinical and echocardiographic outcomes.
Persistent MR after CRT identifies higher-risk patients; extends prior observations but leaves causal questions and targeted interventions open.
CRT can reduce moderate or severe baseline MR to non-significant in one-third of patients. However, its persistence was associated with worse clinical evolution, greater incidence of arrhythmic events, and less reverse remodelling.
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Cabrera‐Bueno et al. (2009) studied this question. Cardiac resynchronization therapy reduced moderate or severe mitral regurgitation to non-significant levels in one-third of patients but its persistence worsened clinical outcomes.
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