Key result
CLOSE-guided ablation linked to ~26-point improvement in AFEQT scores at 12 months.
Why the study?
CLOSE-guided pulmonary vein isolation increases clinical success in paroxysmal atrial fibrillation, but healthcare utilisation, quality of life outcomes, and factors associated with lack of improvement required evaluation.
Does CLOSE-guided pulmonary vein isolation improve quality of life and reduce healthcare utilisation in patients with drug-refractory paroxysmal atrial fibrillation?
Does CLOSE-guided pulmonary vein isolation improve quality of life and reduce healthcare utilisation in patients with drug-refractory paroxysmal atrial fibrillation?
Effect estimate: null (95% CI null)
Absolute Event Rate: 87.2% vs 61.3%
p-value: p=<0.001
Standardized CLOSE-protocol pulmonary vein isolation significantly improves quality of life and reduces cardiovascular hospitalizations and cardioversions at 1 year in patients with drug-refractory paroxysmal atrial fibrillation.
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CLOSE-guided ablation was associated with QOL gains in paroxysmal AF; hypothesis-generating for standardized PVI, pending randomized confirmation.
Gupta et al. (2021) studied Paroxysmal Atrial Fibrillation (PAF) (n=329). CLOSE-guided ablation vs. null was evaluated on Quality of Life (QOL) improvement measured by AFEQT score (null, 95% CI null, p=<0.001). CLOSE-guided ablation significantly improved the AFEQT score from 61.3 to 87.2, indicating a mean improvement of 25.7 points (p<0.001) at 12 months post-procedure.
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