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September 2, 2018European Heart Journal - Cardiovascular PharmacotherapyOpen Access

Effect of oral β-blocker treatment on mortality in contemporary post-myocardial infarction patients: a systematic review and meta-analysis

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Why the study?

Does oral β-blocker treatment reduce all-cause mortality in contemporary post-myocardial infarction patients?

Population

Contemporary post-myocardial infarction patients (AMI survivors)

Design

Meta-analysis

Key result

Oral β-blocker treatment showed no association with all-cause mortality in contemporary post-myocardial infarction patients.

Authors

MAMagnus Dahl AarvikISIrene SandvenTDTatendashe Bernadette Dondo

Discussion

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Overview

Questions routine oral β-blocker use post-MI; challenges prior consensus and supports RCTs to clarify contemporary role.

Key Points

  • To determine the relationship between oral β-blocker treatment and mortality in post-myocardial infarction patients.
  • Conducted a systematic review
  • Performed meta-analysis
  • Included studies assessing mortality after β-blocker treatment
  • No association found between β-blocker treatment and all-cause mortality
  • Potential benefits for acute myocardial infarction survivors warrant further investigation

Structured PICO

Does oral β-blocker treatment reduce all-cause mortality in contemporary post-myocardial infarction patients?

P
Population
Contemporary post-myocardial infarction patients (AMI survivors)
I
Intervention
Oral β-blocker treatment
O
Outcome
All-cause mortalityhard clinical

This meta-analysis suggests that routine oral beta-blocker treatment may not reduce all-cause mortality in contemporary post-myocardial infarction patients, highlighting the need for large randomized clinical trials.

Cite This Study

Aarvik et al. (2018) studied this question. Oral β-blocker treatment showed no association with all-cause mortality in contemporary post-myocardial infarction patients.

synapsesocial.com/papers/69697d6d8374bfe05cda3467https://doi.org/10.1093/ehjcvp/pvy034
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Does Oral Beta-Blocker Therapy Improve Long-Term Survival in ST-Segment Elevation Myocardial Infarction With Preserved Systolic Function? A Meta-Analysis2015 · 41 citations
  2. 2β-Blockers and Cardiovascular Events in Patients With and Without Myocardial Infarction2014 · 111 citations
  3. 3β-Blocker Therapy in the Era of Primary Percutaneous Intervention for ST Elevation Myocardial Infarction2015 · 20 citations
  4. 4β-Blocker Use and Clinical Outcomes in Stable Outpatients With and Without Coronary Artery Disease2012 · 439 citations
  5. 5Decline in Rates of Death and Heart Failure in Acute Coronary Syndromes, 1999-20062007 · 880 citations