Functional-group compatible electrooxidation synthesis of the key antibiotic intermediate rifamycin O

Key Points

• To develop a method for synthesizing rifamycin O by electrooxidizing rifamycin B.
• Electrooxidation of rifamycin B (RB)
• Trace water addition to enhance efficiency
• Evaluation of yield and space–time yield
• Achieved high yield of rifamycin O
• Increased efficiency in the synthesis process