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Observational study explores inflammation in cortical superficial siderosis linked to cerebral amyloid angiopathy, suggesting a broader inflammation spectrum.
The role of inflammation in cortical superficial siderosis (cSS), a marker of cerebral amyloid angiopathy (CAA) linked to high hemorrhage risk, is unclear. We examined 15 patients with cSS using 3 T post‐contrast vessel wall MRI (VWI) and CSF analysis. Although only 27% met current CAA‐ri criteria, 93% showed vessel wall enhancement or sulcal hyperintensities near cSS, frequently extending beyond. Seven patients with follow‐up VWI demonstrated corticosteroid‐responsive regression of inflammation. CSF albumin quotients, indicating blood–brain barrier dysfunction, correlated with MRI inflammation scores. These findings reveal subclinical meningovascular inflammation in cSS and support VWI for detecting a broader CAA‐related inflammation spectrum.
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Arndt et al. (2026) studied this question.
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