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August 9, 2026Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

Cerebral Microbleeds and Superficial Siderosis: Vascular Correlates and Cognition in a Memory Clinic

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Authors

HAHessah Ateeq AlotibiUniversity Health NetworkJVJuan‐Camilo Vargas‐GonzálezUniversity Health NetworkPAPaula Alcaide-LeonUniversity of Toronto

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Overview

Retrospective review of vascular correlates and cognitive impact in a memory clinic, indicating diagnostic relevance.

Key Points

  • The research aims to explore the relationship between cerebral microbleeds, superficial siderosis, and cognitive impairment in memory clinic patients.
  • Retrospective analysis of 2923 patients with cognitive complaints who underwent brain MRI from 2014-2022.
  • Comparison between 137 patients with CMBs and/or cSS and 278 controls without hemorrhagic findings at a 2:1 ratio.
  • Assessment of white matter hyperintensities, lesion location, and cognitive performance using Mini-Mental State Examination and Montreal Cognitive Assessment.
  • CMBs and/or cSS were found in 4.7% of patients, with 22.6% meeting criteria for probable CAA.
  • The CMB/cSS group exhibited higher hypertension rates and increased white matter hyperintensity burden.
  • Lower education levels were identified as a significant predictor of cognitive performance, surpassing the impact of CMBs or cSS.

Cite This Study

Alotibi et al. (2026) studied this question.

synapsesocial.com/papers/6a782d2c2e1896536c83ff20https://doi.org/10.1017/cjn.2026.10634
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