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May 8, 2026European Stroke JournalOpen Access

Abstract Number: Esoc2026a2117 Associations of Cerebral Microbleeds in Cadasil

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Authors

SNSam NeilsonKMKW Muir

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Overview

Randomized trial investigates associations of cerebral microbleeds and disease markers in CADASIL, suggesting implications for clinical assessment.

Key Points

  • This research aims to explore the clinical and radiological associations of cerebral microbleeds in patients with CADASIL.
  • Cohort comprised of genetically confirmed CADASIL cases; N=88 participants
  • Routine MRIs reviewed, with CMB counts derived from GE or SWI sequences
  • Clinical and radiological features compared across groups based on CMB count.
  • 68.2% of participants had no microbleeds; 15.9% had few, and 15.9% had many microbleeds.
  • High CMBs group had a median of 7.5 CMBs and exhibited numerically higher levels of hypertension, stroke history, and advanced NOTCH3-SVD stage.
  • CMBs showed a strong correlation with other small vessel disease markers like lacunes and white matter hyperintensity volume.

Cite This Study

Neilson et al. (2026) studied this question.

synapsesocial.com/papers/69fd7e00bfa21ec5bbf06374https://doi.org/10.1093/esj/aakag023.980
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Associations Between Cerebral Microbleed Patterns and Incident Dementia: The ARIC-Neurocognitive Study2026 · 1 citations
  2. 2Varying Impacts of MRI-Detected Lesions on Cognitive Function in CADASIL Patients2025
  3. 3Cerebral Microbleeds and Superficial Siderosis: Vascular Correlates and Cognition in a Memory Clinic2026
  4. 4Cerebral Microbleeds with a Venous Connection on 3 Tesla Susceptibility-Weighted Imaging in Persons with Alzheimer’s Disease and Healthy Aging Controls2025
  5. 5Association Between Cognitive Impairment and Multimodal MRI Markers in Patients with Cerebral Microbleeds: A Retrospective Case–Control Study2026