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September 16, 2025European PsychiatryOpen Access

Varying Impacts of MRI-Detected Lesions on Cognitive Function in CADASIL Patients

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Authors

JPJoon Hyuk ParkHYHye Jeong YangSLS. H. Lee

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Overview

Observational analysis shows varied cognitive effects linked to MRI lesions in CADASIL patients, indicating significant risks for dementia.

Key Points

  • Total WMH volume is significantly correlated with cognitive performance and dementia diagnosis in CADASIL patients.
  • The prevalence of dementia among CADASIL patients is 18.5%, with specific MRI lesions impacting cognitive function differently.
  • JVWMH and PVWMH volumes show significant links to performance on cognitive tests, while DWMH volume does not.
  • Lacunar infarcts are associated with visual search speed, implying specific lesion impacts on cognitive tasks.

Cite This Study

Park et al. (2025) studied this question.

synapsesocial.com/papers/68d454d131b076d99fa5a6bdhttps://doi.org/10.1192/j.eurpsy.2025.527
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